Ferritin >1000: grand for hemochromatosis screening?
نویسندگان
چکیده
منابع مشابه
Screening for hemochromatosis by measuring ferritin levels: a more effective approach.
Because the penetrance of HFE hemochromatosis is low, traditional population screening measuring the transferrin saturation is unlikely to be cost-effective because the majority of subjects detected neither have clinical disease nor are likely to develop it. Three independent studies show that only patients with serum ferritin concentrations more than 1000 microg/L are at risk for cirrhosis, on...
متن کاملSerum ferritin is a biomarker for liver mortality in the Hemochromatosis and Iron Overload Screening Study.
BACKGROUND We identified no reports of long-term follow-up of participants in hemochromatosis screening programs. We evaluated causes of death and survival in non-C282Y homozygous Canadian participants in the primary care-based hemochromatosis and iron overload screening (HEIRS) study. MATERIAL AND METHODS Initial screening (IS) included transferrin saturation (TS), serum ferritin (SF), HFE g...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Screening for hemochromatosis by measuring ferritin levels: a more effective approach
Because the penetrance of HFE hemochromatosis is low, traditional population screening measuring the transferrin saturation is unlikely to be cost-effective because the majority of subjects detected neither have clinical disease nor are likely to develop it. Three independent studies show that only patients with serum ferritin concentrations more than 1000 g/L are at risk for cirrhosis, one of ...
متن کاملScreening for Hereditary Hemochromatosis: Systematic Review
Introduction Background Methods Data Synthesis Discussion Conclusions References Notes Copyright and Source Information
متن کاملIdiopathic hemochromatosis: serum ferritin concentrations during therapy by phlebotomy.
We report the case of a 54-year-old man who presented with symptoms of idiopathic hemochromatosis, an inherited disorder involving regulation of iron absorption. These symptoms usually do not appear until total body iron content reaches 15 g, about threefold normal. Therapy involves mobilization and removal of excess stored iron through weekly or twice-weekly phlebotomies of 500 mL, until the h...
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ژورنال
عنوان ژورنال: Blood
سال: 2008
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2008-01-127118